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LPS indirect action involves the Toll-Like Receptor 4 (TLR4)-Cluster of Differentiations 14 (CD14)-dependent pro-inflammatory response

Research has shown that weekly injections at higher doses may promote fracture healing to a similar extent as daily lower-dose injections in rodent models, though human verification of weekly protocols is still in progress

These may include: Deep vein thrombosis (DVT): This condition occurs when a blood clot forms in the deep veins of the lower leg, and it can cause swelling and pain in the back of the knee

A commenter noted that extrapolation from the results of the 8-month pilot test in the hospital outpatient department shows that only 38 percent of facilities would have reached the threshold of 200 completed surveys over the course of a year

Pregnancy and lactation No published human reproductive or lactation safety data exists