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Gut dysbiosis and inflammation can alter tryptophan (the precursor to serotonin) metabolism to the kynurenine (KYN) pathway, which is linked to the development of a range of different mental illnesses (24)

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Our team has observed that for studies focusing on long-term, sustained NNMT inhibition where slight variations in peak plasma concentration aren't catastrophic, the oral route might be sufficient

It is studied in laboratory models for innate-repair-receptor signaling pathways, notably without the erythropoietic activity of the parent molecule

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Kennon-McGill S, McGill MR