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ROS level was measured in WI-38 cells treated with 150uM hydrogen peroxide (H 2 O 2 ), with or without pretreatment of GHKCu

These paradoxical results could be observed in some other studies, such as the Keap1-Nrf2 axis in acute lung injury, in which Keap1 expression increased in some animal and in vitro experiments (Huang et al., 2020