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Inhibiting COX-2 attenuated the rise of COX-2 levels and epithelial-mesenchymal transition (EMT) scores in NPC cells driven by MDSCs, suggesting COX-2 as a critical checkpoint for MDSCtumor cell interactions and tumor promotion [47]

[15,40] Even with modern modifications, the most recent studies have not observed any significant improvement with this treatment option

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X-ray crystallography led to an increasing number of PPO structures 22,23,24,25,26

After incubation of the secondary antibody, Alexa Flour 488-conjugated goat anti-rabbit IgG (Thermo Fisher), cells were resuspended in 200 l PBS/1% BSA and measured on a BD FACS Canto II flow cytometer (BD Bioscience)