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ADP1 can utilize a variety of G- and H-type lignin monomers via the native -ketoadipate pathway and has been shown to have ligninolytic effects on softwood [40, 41]

Materials and methods Cells and culture conditions Two different human myeloid leukaemia U937 cell lines producing 1050 ng ml 1 of hGH after stable gene transfer (U937-hGH-A and U937-hGH-H5) and the control line (U937-Neo), already described (Haeffner et al, 1999), were maintained in regular FCS-enriched RPMI 1640 medium (Bio-Whittaker Europe, Verviers, Belgium) containing 0.5 mg ml 1 of G418 (Life Technology, Paisley, Scotland)

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The first indication of a metabolic difference between normal and cancer cells was identified in 1924 by Otto Heinrich Warburg, who identified an abnormality in glucose metabolism

Adibekian, A., Hsu, K