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Most severe COVID-19 cases exhibit an extreme increase in inflammatory cytokines, including IL-1, IL-2, IL-6, IL-7, IL-8, IL-10, granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), interferon-inducible protein-10 (IP10), monocyte chemotactic protein 1 (MCP1), macrophage inflammation protein-1, IFN-, and TNF-, 2,3,12,15 representing a cytokine storm

Any of these will knock you out

The observed alterations in energy and lipid metabolism present promising therapeutic avenues for alleviating symptoms in these patient populations

PMID 16705108

10.1007/s12035-012-8318-1 Mol