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7 Future perspectives Model organisms are important substitutes for human studies to facilitate and expedite translation of preclinical studies

This dotted appearance is observed in other studies as an indicator of fragmented mitochondria in unhealthy and oxidatively stressed cells (Jeek and Plecit-Hlavat, 2009)

This, in turn, upregulates SLC7A11 expression, enhances the levels of GPX4, GSH, and SOD, and reduces Fe 2+ and MDA levels, thereby suppressing ferroptosis and promoting BV2 cell survival

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In the past years, there has been notable progress in understanding the transcript expression profile during salinity adaptation of various euryhaline teleost species using RNA-Seq, such as Nile tilapia ( Oreochromis niloticus ), Mozambique tilapia ( Oreochromis mossambicus ) ( Table 2 ) (Ronkin et al., 2015), medaka ( Oryzias melastigma ) (Lai et al., 2015), striped catfish ( Pangasianodon hypophthalmus ) (Thanh et al., 2015