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Kell DB, Pretorius E

issues overseas

Not the garish kind that shouts for attention but a subtler, more insidious intimacy

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In hepatocellular carcinoma (HCC) cells, ketoconazole downregulates the expression of COX2, thereby triggering PINK1-Parkin-mediated mitophagy to enhance apoptosis, downregulate BCL2, BCL-XL and MCL1 and upregulate BAX and BAK [25] (Fig