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But high blood levels of B12 do not mean symptoms are well treated

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Clinically, the syndrome presents with a mlange of mostly non-specific symptoms including unrelenting fatigue persisting over more than 6 months, exertional intolerance, sleep disturbance, abnormal function in the cognitive, emotional, speech and memory domains, hypersensitivity to light and noise, psychomotor slowness and orthostatic intolerance ( On the pathobiological level, ME/CFS is no less complex

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Moreover, the overall deficit in BDNF levels can lead to an imbalance in excitatory/inhibitory neurotransmission, including dysregulation of GABAergic transmission, ultimately leading to neurodegeneration (Kim et al