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Gomes et al 2 demonstrated that MMA levels are also increased with age and that high MMA levels promote tumor progression by reprogramming lung and breast cancer cells to adopt aggressive properties, such as increased metastasis

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Mice in the vehicle cohort received three subcutaneous (SC) saline (1 ml/kg) injections/day (0930, 1330, 1730 h) and mice in the treatment cohort received three SC injections of the NNMT inhibitor 5-amino-1MQ at a dose of 20 mg/kg/injection for a total dose of 34 mg/kg/day of the parent compound (calculated according to free weight) for 11 days

2011;208(3):R9r16

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