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Behind the scenes, FDA Commissioner Marty Makary resigned amid reports of disagreements between the FDA and the White House administration on the agencys approach to tobacco and nicotine regulation

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The computers grouped the sequences into about 20 distinct categories, or mutational signatures. Mutations tied to five of these signatures were more common in tumors from smokers than in tumors from nonsmokers

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Altria, meanwhile, has invested $12.8 billion in e-cigarette upstart Juul, which has catapulted itself to the U.S