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Another aspect of the invention pertains to the use of small molecule quinoline derived cations of Formula IA for muscular therapy, wherein: the cation of Formula IA includes two or more non-hydrogen substituents, and wherein: R 5 is H or NH 2 , R 6 is H or F

Introduction Cluster of differentiation 38 (CD38) is a cell surface glycoprotein and multifunctional extracellular enzyme which is primarily a NAD + glycohydrolase and ADPR cyclase ( + ) hydrolase, most of the NAD + catalyzed by CD38 is converted to adenosine diphosphate-ribose (ADPR), and a few molecules are cyclized to form cADPR by ADPR cyclase ( + ( As a cell surface receptor, CD38 is necessary for immune cell activation and proliferation