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The mean tetranor-PGEM concentration in male patients with FCMD, age-matched to ones with DMD in a previous study 12 , was 29.5 5.1 ng/mg creatinine, which is significantly higher than that of patients with DMD

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The viscosity of the synovial fluid decreases due to the depolymerization of hyaluronic acid in the absence of hyaluronidase enzyme and no depletion in hyaluronic acid by synovial fluid proteases