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Pomegranate-derived exosome-like nanovesicles alleviate Binge alcohol-Induced leaky gut and liver injury

10.1039/c5ra13559a RSC Adv

Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]

Moreover, the analysis highlights the need to learn from best practices observed in countries such as Nigeria, Myanmar, Chad, and the Central African Republic, which comprehensively address urban water challenges and responses for both mitigation and adaptation