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In fact, in vivo studies have shown that Nrf2 signaling has an essential role in limiting neuropathies (Arruri et al., 2017), arthritis (Ferrandiz et al., 2018), colitis (Xu et al., 2018), pneumonia (Athale et al., 2012), pulmonary fibrosis (Yan et al., 2017), skin diseases (Schafer and Werner, 2015), liver (Bae et al., 2013), and kidney damage (Shen et al., 2017), as well as affecting tumor development (Sporn and Liby, 2012)

The study also recommends studying the impact of VCN on other molecular targets like the apoptotic-related targets (Bcl-2, BAX, and caspase) and the NOX family related to ROS production