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It is difficult to say, but for those already addicted it seems most likely that reducing the effectiveness of nicotine delivery in this way would simply lead to smoking more cigarettes, just as lowering the nicotine content of cigarette tobacco does

In a meta-analysis of studies that use an experimental protocol, Noar et al

Caffeine can increase blood glucose levels and complicate the control of glucose levels in diabetic patients on oral hypoglycemic medications

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