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Withdrawal produces significant craving, irritability, and difficulty concentrating, and relapse rates are extremely high without pharmacological support

12 Suppl 2 (Suppl 2): S110116

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*Correspondence: Yue Chen [email protected] Xu [email protected] This article was submitted to Atherosclerosis and Vascular Medicine, a section of the journal Frontiers in Cardiovascular Medicine These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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