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Song J, Yang X, Jacobson O, Lin L, Huang P, Niu G, et al

However, we found that both Alanine and Cystine substantially fell outside of healthy reference ranges, with Cystine being dramatically reduced in both affected and unaffected siblings with average plasma concentrations of 3.0 mol/L and 3.3 mol/L respectively, while Alanine was found to be elevated regardless of disease status (U:595.5 mol/L, K:589.0 mol/L)

However, this thyroid-stimulating effect also carries a risk of iatrogenic thyrotoxicosis in individuals with normal thyroid function or pre-existing hyperthyroid conditions, such as Graves disease

Jolicoeur P, Tacey RL

10.3389/fphar.2023.1226008 149 ZhaoM.ShaoD.YuL.SunX.WangY.HuH.et al (2015a)