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This has opened the door to more direct methods, and one thats gaining significant traction is nebulization

Proc Natl Acad Sci U S A 1991;88:10638-41

Eisenberg MA, Deboever N, Hofstetter W, Mehran RJ, Rice DC, Rajaram R, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Antonoff MB

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Samuels, a professor at the Oregon Clinical and Translational Research Institute, stated: It is a common clinical observation that some otherwise healthy patients with hypothyroidism continue to complain of fatigue, poor mood, inability to concentrate, and vague cognitive difficulties (often described as brain fog) despite normal TSH levels. [5] 2