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Additionally, the CheckMate 18 phase III clinical trial, focusing on individuals with inoperable or metastatic melanoma, revealed a 43.6% objective response rate (ORR) in PD-L1-positive patients treated with nivolumab, compared to 9.1% in those receiving chemotherapy [116]

It has been demonstrated that MEM preferentially prevents the excessive continuous extrasynaptic NMDAR disease activation and therefore prevents neuronal cell death induced by excitotoxicity without disrupting physiological synaptic activity

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Or will high costs, insurance restrictions, side effect burdens, and supply constraints limit them to a small fraction of eligible patients