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Treatment with propargylglycine (PAG) [16], a pharmacological inhibitor of the key enzyme in the transsulfuration pathway that catalyzes the hydrolysis of cystathionine into cysteine, cystathionine -lyase (CSE), was sufficient to sensitize two MYCN -amplified NB cell lines to system Xc-inhibition ( Fig

Their cleavage conditions are more controllable and predictable

For instance, targeting key metabolic enzymes or using glycolysis inhibitors can reduce lactate production and lactylation levels, thereby enhancing the efficacy of immune checkpoint blockade therapy, improving NK and CD8+ T cell infiltration and counteracting the regulatory T cell expansion caused by MOESIN-K72la (82)

Modulation of IMS redox pathways influences E GSH [IMS] only to a minor extent Due to its proximity to the respiratory chain, the IMS glutathione pool might be influenced by the activity of the respiratory chain, for example, by release of reactive oxygen species (ROS)

Plasma cysteine, cystine, and glutathione in cirrhosis