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Dosing adjustments may be needed

co-administration of pyridoxine has been shown to reduce the blood levels of phenobarbital and phenytoin, possibly diminishing their anticonvulsant efficacy

If you think you may be B12 deficient please see this page;

Ils manquent de trypsine , l'enzyme ncessaire l'absorption de la vitamine B12 [29]

Geoffrey Littlejohn, adjunct clinical professor at Monash University, said the concept needed clarification in a well-conducted double-blind placebo-controlled study