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2025) Methylmalonic acid and neurology MMA accumulation following decreased conversion of methylmalonyl-CoA to succinyl-CoA also impairs TCA cycle flux

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For a patient with a serum vitamin B12 level of 157 pg/mL, what rapid treatment regimen (daily intramuscular injection schedule, followed by weekly and then monthly dosing) can be used to restore normal levels?

Anna WilliamsDerek Pyland

Others who might be prescribed B12 shots are those at the highest risk for a B12 deficiency, including: Vegans, since vitamin B12 is found only in animal products People ages 60 and up since their bodies don't absorb B12 as efficiently People with Crohn's disease or pancreatic disease, since they prevent nutrient absorption People who had weight-loss surgery, which decreases B12 absorption People with an eating disorder People with HIV People with diabetes Since a mild B12 deficiency might not cause symptoms, it can go undetected for years since levels are not checked during routine blood work