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Modelling of the point mutations within the DHFR crystal structure suggested that E173D contributes to a higher conformational flexibility and increases the exposure of Lys side chains on the surface under elevated temperatures

Talanta 174:539547 Urig S, Becker K (2006) On the potential of thioredoxin reductase inhibitors for cancer therapy

The modification provides practical half-life without going to the dramatically extended timeframe of CJC-1295 with DAC

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Monoclonal antibodies are highly specific, being directed against a single antigenic site