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Gameiro PA, Yang J, Metelo AM, Prez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, Lpez-Larrubia P, Stephanopoulos G, Iliopoulos O

This metabolic reprogramming also supplies superoxide production, and induces ROS and hypochlorous acid, used in the neutrophil oxidative burst following phagocytosis of invading pathogens [211, 216,217,218]

Table 2 Summary of recent clinical trials for pharmacological therapies in CTD-ILD

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In studies of human recombinant MTHFR, the protein encoded by 1298C cannot be distinguished from 1298A in terms of activity, thermolability, FAD release, or the protective effect of 5-methyl-THF