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Unlike physiological aging, which unfolds over decades, inflamm-aging is characterized by the activation of pro-inflammatory mediators, such as IL-6, TNF-, and chemokines, which can induce follicular atresia, compromise steroidogenesis, and hasten menopause (Yan et al., 2022)

This also highlights the potential influence of tumor metabolic status (e.g., glycolysis activity) on cuproptosis sensitivity low LDH levels correlate with impaired glycolysis and enhanced mitochondrial metabolism, thereby fostering the metabolic dependencies of cuproptosis

Together, both our in vitro and cell-based assays show that the -loop region of GDAP1 plays a critical role in 4HNE recognition and GDAP1s cytoprotective function in the cell