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Adverse effects of vitamin B12 injections Pro Research Analysisby Searched over 200M research papers Adverse Effects of Vitamin B12 Injections: Hypersensitivity and Anaphylactic Reactions Vitamin B12 injections, especially via the intramuscular route, are widely used to treat vitamin B12 deficiency

[51] Diagnosis [edit] According to one review: "At present, no 'gold standard' test exists for the diagnosis of vitamin B 12 deficiency and as a consequence the diagnosis requires consideration of both the clinical state of the patient and the results of investigations." [52] The vitamin deficiency is typically suspected when a routine complete blood count shows anemia with an elevated mean corpuscular volume (MCV)

It is present at millimolar concentrations intracellularly and performs a foundational role in thiol-based redox signaling, protein function, gene expression, cell differentiation, and cell proliferation

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Genetic factors may also play a role