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Competition from adjacent harm-reduction categories, including chewing tobacco products designed as cigarette substitutes and next-generation nicotine products, creates substitution risk in consumer segments motivated primarily by harm reduction rather than specifically seeking herbal or natural alternatives

Statistical analysis We performed descriptive analyses to obtain the sample characteristics and calculated weighted proportions and 95% confidence intervals (CI) for awareness and use of HTPs by tobacco use status (none, single, dual/poly), past 30 days flavored tobacco use (e.g

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When the tobacco settlement was signed in December 1998, it was portrayed as a massive transfer of wealth from the large tobacco companies to the States