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This value is consistent with the endogenous brain-to-serum concentration ratio of CT [3], suggesting that the BBB functions as a major pathway for supplying CT to the brain from the circulating blood

These mouse models emphasize the dependency of NF1-associated optic pathway glioma on timing of NF1 inactivation, cell-of-origin, and on the tumor microenvironment as NF1 heterozygosity was required for optic glioma formation

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The metabolic properties of cancer cells and tumour-associated stromal cells influence angiogenesis in many ways (for example, by regulating glucose bioavailability to angiogenic blood vessels)

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