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A number of macrolides without antibiotics but with motilin receptor agonistic properties were developed for the treatment of FD and diabetic gastroparesis (103)

PPIs block gastric H+K+-ATPase, which is responsible for pumping H+ ions from within gastric parietal cells into the gastric lumen, where they interact with Cl ions to form HCl

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This is consistent with the gastrointestinal transit time of mice showing no undesirable adhesion of the compound to the GI tract