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doi: 10.1038/nature07823 11

Reactive oxygen species cause damage by lipid peroxidation of the lipids found in cell membranes, causing DNA strand breaks and alteration of proteins such as enzymes

These were then selected further using the one-way analysis of variance (ANOVA) test, followed by a correction for multiple comparisons by controlling the false discovery rate with the two-stage step-up method of Benjamini, Krieger, and Yekutieli, as recommended by the GraphPad Prism software (version 7.0 for Mac OS X)