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The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)

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Ying Y., Wang Y., Huang X., Sun Y., Zhang J., Li M., Zeng J., Wang M., Xiao W., Zhong L., Xu B., Li L., Tao Q., Wang X., Shu X

In terms of epidemiology, the reported prevalence of altitude illnesses varies significantly due to differences in sample size, ethnic population, diagnostic methods/criteria, study design and environmental conditions

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