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Alternatively, this may suggest that mouse microglia perform multiple functions required to clear myelin debris and create a permissive environment for remyelination, but these functions may be diversified in humans and restricted to specific subtypes, consistent with previous reports of evolutionary divergence in human microglia 42

This allows for high bioavailability and faster effects

gingivalis LPS induces ferroptosis in MLOY4 osteocytic models, producing GSH depletion, downregulation of osteogenic genes, including runtrelated transcription factor 2 (RUNX2), osterix (OSX), and osteocalcin (OCN), and impaired mineralized nodule formation (52, 53)

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Pediatr.Endocrinol.Diabetes Metab 2010;16(2):78-81