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Proteasome inhibition results in stabilization of several key tumor suppressing proteins (e.g., NFKB inhibitor alpha [NFKBIA/IKBA] (Li and Dou, 2000), cyclin-dependent kinase inhibitor 1A [CDKN1A/p21] (Pagano et al., 1995), and tumor protein p53 [TP53] (Lopes et al., 1997)), which are responsible for cell growth inhibition or cell death induction

HUVECs plated on Matrigel in limiting medium with increasing concentrations of BPC157 formed more extensive tubes in a dose-dependent manner (Fig

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Many of these plant-based compounds also exhibit anti-angiogenic properties and can enhance the efficacy of conventional therapies (66)