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After invasion into the host, mycobacteria induce NADPH oxidase 2 (NOX2) expression to generate superoxide radicals (O 2 ), which are then converted to more toxic hydrogen peroxide (H 2 O 2 ) by superoxide dismutase (SOD) and subsequently reduced to water and molecular oxygen by catalase [57, 58]

It also significantly reduced inflammatory markers TNF-alpha and destructive enzymes MMP-2/MMP-9

More studies need to be conducted to test whether repeated dosing could help the drug penetrate further over time

On the final day, following a 12-h fast (with water provided ad libitum ), mice were anesthetized with 3% isoflurane